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Topic Title: Korean scientists develop new hair loss drug
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Created On: 11/23/2017 09:24 AM
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 11/23/2017 09:24 AM
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topcat
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Here you go Junior this is good too...........it's all information the more the better.

Korean scientists develop potential drug candidate for hair loss

By Sohn Ji-young
Published : Nov 21, 2017 - 15:29 Updated : Nov 21, 2017 - 18:49
South Korean scientists have developed a biochemical substance that instigates new hair follicle growth, opening new doors in the realm of hair loss treatments, which have been limited to slowing hair loss or accelerating growth, rather than regeneration, experts said.

The Korean Ministry of Science and ICT said Monday that a team of researchers led by Yonsei University's professor Choi Kang-yell has developed a potential drug candidate targeting a protein that prohibits new hair follicle growth.

The research was funded by the Science Ministry as part of its basic science research support program.






Choi's team has discovered a protein called CXXC-type zinc finger protein 5 that binds to the Dishevelled protein. The binding protein interrupts the Wnt signaling pathway that instigates hair follicle development and regeneration in adults.

Based on this finding, the researchers have developed a biochemical substance, PTD-DBM, that prevents CXXC from binding with the Dishevelled protein. When the substance was applied on the bare skin of laboratory mice, they saw new hair follicle growth.

This study was published in a research paper titled "Targeting of CXXC5 by a Competing Peptide Stimulates Hair Re-growth and Wound-Induced Hair Neogenesis" in the Journal of Investigative Dermatology last month.

"Disrupting the CXXC5-Dishevelled interaction with a competitor peptide activated the Wnt/?-catenin pathway and accelerated hair regrowth and wound-induced hair follicle neogenesis," the paper said.



The new drug candidate in development differs from existing baldness treatments like MSD's Propecia (finasteride) designed to slow down hair loss, or drugs that speed up the growth of existing hair. Such treatments have been limited in their scope, as they cannot be used to treat cases of baldness where there are no hair follicles left.

Moreover, existing hair loss drugs are known to induce a number of common side effects, including impotence and abnormal ejaculation caused by hormonal changes as well as swelling and dizziness.

Given this, the development of a safe substance that induces follicle regeneration opens new possibilities in the development of baldness-fighting drugs, the Seoul-based research team said.

"This newly developed substance is a first-in-class drug candidate. It is expected to become a treatment for not only hair loss and baldness but also for regenerating damaged skin tissue," said Choi who led the research.

Taking the next step, the team is now conducting laboratory animal tests to discern whether PTD-DBM possesses toxic characteristics, it said.

Hair loss affects millions of men and women around the world, yet a cure has not been developed despite decades of research. Current hair loss treatments only manage hair loss symptoms, rather than providing a permanent solution.

There are only two drugs approved by the US Food and Drug Administration for treating hair loss: minoxidil, sold by Pfizer under the name Rogaine, and finasteride, which is sold by MSD under the name Propecia.

By Sohn Ji-young ()


Article

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Stay away from doctors who perform mega sessions, have posts deleted, attack posters, sue patients & forum owners, use power drills or robots. I recommend fue with hand punches in the .70-.85 range. I consulted with dozens of clinics over the years and there was a recurring theme regarding FUE among some employees of those other clinics. I was told Bisanga was the man my research told me the same and my experience validated my own research.
 11/23/2017 07:49 PM
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Skywalker
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When the substance was applied on the bare skin of laboratory mice


I saw this too, but it's f******g mice again - it's always mice - we've been giving mice Elvis style hair for over a decade but to date it has always meant f*** all when it comes to humans

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A 'Government Study' is not necessarily proof - "Garbage In, Garbage Out".

Have not had an HT, turned down by 3 clinics, sadly they were right, my donor area has miniaturised.
Now here to look for any advances and give newbies another opinion.

The guy in the centre of my icon doing the inspection of scars is the ideal potential HT candidate:- Doubting Thomas
 11/23/2017 08:19 PM
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Myboyblue13
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I'll take just about any drug that'll give me hair like I had when I was 18. Sign me up for updates on this!
 12/05/2017 05:38 PM
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taco
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any idea when this would be available?
Will it take 5yrs like in the USA
 12/06/2017 02:55 PM
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topcat
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If you look at technology and medical technology in general it is moving forward exponentially faster and faster. One must weigh the benefits versus the risks with what is available today and ask themselves does it makes sense to wait and in my opinion that answer is yes. Of course marketers will try and convince young guys to have a hair transplant when the numbers don't quite add up yet. Use medication which may very well have long term consequences or inject ink dots into their head.

The first human genome took $2.7 billion and almost 15 years to complete. Now, according to Cowen analyst Doug Schenkel, genome sequencing and analysis cost around $1,400. The sequencing can be done in a few days

Does this matter of course it does it show exactly the speed at which advances are happening.

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Stay away from doctors who perform mega sessions, have posts deleted, attack posters, sue patients & forum owners, use power drills or robots. I recommend fue with hand punches in the .70-.85 range. I consulted with dozens of clinics over the years and there was a recurring theme regarding FUE among some employees of those other clinics. I was told Bisanga was the man my research told me the same and my experience validated my own research.
 12/14/2017 02:54 PM
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x
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Don't want to throw cold water on this but several years back they showed the results of Wnt signaling experiments they were trying with rats and they had tumors all over their heads. This could be something different entirely using other pathways but just saying that there's probably going to be a lot of testing with this before it hits the market, if ever.
 12/15/2017 02:28 AM
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topcat
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I might focus more on the speed at which technology/medical technology is moving and yes this drug could easily result in failure. On the bright side as stated everything is speeding up and one does not risk much by waiting for this process as it does.

I think when you weigh the risk of surgery along with the limitations then waiting for something new seems to be the better option most especially for the very young guys. Young guys don't understand that taking even single hairs from the back of their head and placing them at 50% density which is the best most can hope for can look odd even with the best surgeon. This seems to be less the case for older guys as the hair thins/grays and they are realistic. in their expectations with a high hairline and just having some coverage.

Then you add in what has gone on with the online marketing of the procedure and waiting for the sped up process of new advancements makes sense. Much of the online marketing can be compared to the Harvey Weinstein case which is now going class action/racketeering. Variety magazine has an interesting quote which rings a bell for those familiar with the online marketing of ht. There has very often been a concerted effort to work together in the marketing effort while removing truths. As stated young guys should wait time is now on your side.

This is not to infer that everyone is dishonest in the hair game but enough are that young guys would be much safer waiting. We assume people are good because of the image they present but that is not always the case. Just look at the news........seems like a lot of good decent people are also rapists............it's bizarre because it does not match the image in our heads..........it's creates cognitive dissonance but it's reality so we need to come to terms with it so we can make better decisions is every area of our life.

More clinics should support this site because if they are honest what someone else has to say should not matter...........just keep being honest and doing great work.........it's pretty simple.................but of course if one is not honest then I can see how it can be a problem.


"Rather, over time, Weinstein enlisted the aid of other firms and individuals to facilitate and conceal his pattern of unwanted sexual conduct. This coalition of firms and individuals became part of the growing 'Weinstein Sexual Enterprise,' a RICO enterprise."

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Stay away from doctors who perform mega sessions, have posts deleted, attack posters, sue patients & forum owners, use power drills or robots. I recommend fue with hand punches in the .70-.85 range. I consulted with dozens of clinics over the years and there was a recurring theme regarding FUE among some employees of those other clinics. I was told Bisanga was the man my research told me the same and my experience validated my own research.

Edited: 12/16/2017 at 05:00 PM by topcat
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